3-[(1-benzyl-4-piperidyl)oxy]propanenitrile → 200868-41-3
반응식
[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([O:14][CH2:15][CH2:16][C:17]#[N:18])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H][H]>C(O)C.[Ni]>[CH2:1]([N:8]1[CH2:9][CH2:10][CH:11]([O:14][CH2:15][CH2:16][CH2:17][NH2:18])[CH2:12][CH2:13]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1참가 물질
5
실험 절차
10.0 g (40.9 mmol) 3-(1-benylpiperidin-4-yloxy)-propionitrile are dissolved in 100 ml ethanol and added to a spatula tip of Raney-Nickel. The mixture is stirred at RT under hydrogen atmosphere until the uptake of the theoretical amount of hydrogen (ca. two days). The mixture is filtered from the catalyst and the solvent is removed under vacuum. The residue is distilled in a bulb tube apparatus. Yield of colorless oil: 7.5 g (73%).
후처리
- filtrationThe mixture is filtered from the catalyst
- customthe solvent is removed under vacuum
- distillationThe residue is distilled in a bulb tube apparatus
출처 및 근거
- ORD 기록
- ord-8f0bc9ba11564026af81e54f68306f68
- 출처 데이터셋
- uspto-grants-2007_07
- 특허 번호
- US07241745B2
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