N-[3-fluoro-2-(hydroxyl-o-tolyl-methyl)-phenyl]-acetamide → N-[3-fluoro-2-(2-methyl-benzoyl)-phenyl]-acetamide

HRID 1294568노트

반응식

HRID 1294568 반응식
[F:1][C:2]1[C:3]([CH:12]([OH:20])[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[CH3:19])=[C:4]([NH:8][C:9](=[O:11])[CH3:10])[CH:5]=[CH:6][CH:7]=1>C(Cl)(Cl)Cl.[O-2].[Mn+4].[O-2]>[F:1][C:2]1[C:3]([C:12](=[O:20])[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[CH3:19])=[C:4]([NH:8][C:9](=[O:11])[CH3:10])[CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 1

HCID 69489997N-[3-fluoro-2-(hydroxyl-o-tolyl-methyl)-phenyl]-acetamide

생성물 1

HCID 69489411N-[3-fluoro-2-(2-methyl-benzoyl)-phenyl]-acetamide

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6212Chloroform용매

실험 절차

205 mg (0.75 mmol) N-[3-fluoro-2-(hydroxyl-o-tolyl-methyl)-phenyl]-acetamide are dissolved in 9 ml chloroform, combined with 652 mg (7.5 mmol) manganese(IV)-oxide and stirred for 3 d at ambient temperature. Then excess manganese(IV)-oxide is filtered off through Celite and the solvent is eliminated in vacuo. The crude product is purified by column chromatography. The carrier material used is silica gel and the eluant used is a mixture of cyclohexane:ethyl acetate (80:20).

후처리

  1. filtrationThen excess manganese(IV)-oxide is filtered off through Celite
  2. customThe crude product is purified by column chromatography
  3. additiona mixture of cyclohexane:ethyl acetate (80:20)

출처 및 근거

ORD 기록
ord-0a32ff9d21694fd790aba529c9ff32d8
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07241769B2

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