Hydrochloric Acid → (2-Amino-6-fluoro-phenyl)-o-tolyl-methanone

HRID 1294569노트

반응식

HRID 1294569 반응식
[F:1][C:2]1[C:3]([C:12](=[O:20])[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[CH3:19])=[C:4]([NH:8]C(=O)C)[CH:5]=[CH:6][CH:7]=1.Cl.O.C(=O)([O-])[O-].[Na+].[Na+]>C(O)C>[NH2:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[C:3]=1[C:12]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[CH3:19])=[O:20]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 10340Sodium CarbonateHCID 69489411N-[3-fluoro-2-(2-methyl-benzoyl)-phenyl]-acetamide

생성물 1

HCID 58906377(2-Amino-6-fluoro-phenyl)-o-tolyl-methanone

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
70 °C

실험 절차

142 mg (0.52 mmol) N-[3-fluoro-2-(2-methyl-benzoyl)-phenyl]-acetamide are dissolved in 2 ml of ethanol, combined with 2 ml of conc. hydrochloric acid and stirred for 4 h at 70° C. Then the reaction mixture is stirred into 30 ml dist. water, adjusted to pH 7 with sodium carbonate and extracted three times with 10 ml of ethyl acetate. Then the organic phase is dried with MgSO4 and the solvent is eliminated in vacuo.

후처리

  1. stirringThen the reaction mixture is stirred into 30 ml dist
  2. extractionextracted three times with 10 ml of ethyl acetate
  3. dry with materialThen the organic phase is dried with MgSO4

출처 및 근거

ORD 기록
ord-fe5e17c8541246c4a9fdfc9f3fed9baa
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07241769B2

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