2-Amino-4-methylpyridine → 7-Methyl-3-(2-methyl-2-nitropropyl)imidazo[1,2-a]pyridine

반응식

[NH2:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][N:3]=1.Br[CH:10]([CH2:13][C:14]([CH3:19])([N+:16]([O-:18])=[O:17])[CH3:15])[CH:11]=O>>[CH3:8][C:6]1[CH:5]=[CH:4][N:3]2[C:10]([CH2:13][C:14]([CH3:19])([N+:16]([O-:18])=[O:17])[CH3:15])=[CH:11][N:1]=[C:2]2[CH:7]=1

참가 물질

반응물 2

HCID 15332-Amino-4-methylpyridine

HCID 220385582-Bromo-4-methyl4-nitropentanal

생성물 1

HCID 220385657-Methyl-3-(2-methyl-2-nitropropyl)imidazo[1,2-a]pyridine수율 63.4%

실험 절차

2-Amino-4-methylpyridine (2.2 g, 20.3 mmol) and 2-bromo-4-methyl-4-nitropentanal (20.3 mmol) are reacted as described in Amine 7 to give 3.0 g of 7-methyl-3-(2-methyl-2-nitropropyl)imidazo[1,2-a]pyridine (63%).

출처 및 근거

ORD 기록: ord-71b6eed1b6414c1d8a0b16bc360157e1
출처 데이터셋: uspto-grants-2007_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07241772B2

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