Hydrochloric Acid → 3-[4-(thien-3-yloxy)phenoxy]quinuclidine Hydrochloride

HRID 1294664

반응식

HRID 1294664 반응식
[S:1]1[CH:5]=[CH:4][C:3]([O:6][C:7]2[CH:21]=[CH:20][C:10]([O:11][CH:12]3[CH:17]4[CH2:18][CH2:19][N:14]([CH2:15][CH2:16]4)[CH2:13]3)=[CH:9][CH:8]=2)=[CH:2]1.[ClH:22].O1CCOCC1>C(OCC)(=O)C>[ClH:22].[S:1]1[CH:5]=[CH:4][C:3]([O:6][C:7]2[CH:8]=[CH:9][C:10]([O:11][CH:12]3[CH:17]4[CH2:16][CH2:15][N:14]([CH2:19][CH2:18]4)[CH2:13]3)=[CH:20][CH:21]=2)=[CH:2]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 112203553-[4-(Thien-3-yloxy)phenoxy]quinuclidine

생성물 1

HCID 695200113-[4-(thien-3-yloxy)phenoxy]quinuclidine Hydrochloride

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

The product of Example 15E (40 mg, 0.13 mmol) in ethyl acetate (4 mL) was treated with 4M HCl in 1,4-dioxane (0.2 mL, 0.8 mmol). The title compound was obtained as a solid (26 mg, yield, 59%). 1H NMR (MeOH-d4, 300 MHz) δ 1.80–2.10 (m, 3H), 2.25–2.46 (m, 1H), 2.56 (m, 1H), 3.30–3.50 (m, 5H), 3.80 (m, 1H), 4.85 (m, 1H), 6.55 (dd, J=3.4, 1.7 Hz, 1H), 6.81 (dd, J=5.5, 1.7 Hz, 1H), 6.97 (dt, J=9.5, 3.0 Hz, 2H), 7.02 (dt, J=9.5, 3.1 Hz, 2H), 7.34 (dd, J=5.1, 3.1 Hz, 1H) ppm. MS (DCl/NH3) m/z 302 (M+H)+. Anal. Calculated for C17H19NO2S.1.0HCl.0.5H2O: C, 58.86; H, 6.10; N, 4.04. Found: C, 59.08; H, 5.88; N, 4.06.

출처 및 근거

ORD 기록
ord-dcbfd6f99d5646e286e1ca3b4541c363
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07241773B2

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