Hydrochloric Acid → Ethyl 2-(2-methylpyridin-3-yl)ethanimidoate hydrochloride

HRID 1294704

반응식

HRID 1294704 반응식
[CH3:1][C:2]1[C:7]([CH2:8][C:9]#[N:10])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH2:11]([OH:13])[CH3:12].[ClH:14]>C(Cl)Cl>[ClH:14].[CH3:1][C:2]1[C:7]([CH2:8][C:9](=[NH:10])[O:13][CH2:11][CH3:12])=[CH:6][CH:5]=[CH:4][N:3]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 190992862-(2-Methylpyridin-3-yl)acetonitrile

생성물 1

HCID 69411260Ethyl 2-(2-methylpyridin-3-yl)ethanimidoate hydrochloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Through a stirred solution of Example 20A (1.7 g, 12.86 mmol) in absolute ethanol (0.89 g, 19.35 mmol) and anhydrous methylene chloride (25 ml) was bubbled with hydrogen chloride gas for 20 min. The mixture was allowed to stand overnight in the refrigerator. The product was precipitated with anhydrous ether and filtered to obtain the title compound, which was immediately used in the next step. MS (ESI+) m/z 180 (M+H)+.

후처리

  1. customThe product was precipitated with anhydrous ether
  2. filtrationfiltered

출처 및 근거

ORD 기록
ord-f5ea94eab2534c5faee47406155d52cb
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07241776B2

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