1-Iodopentane → 7-chloro-3-(4-methoxyphenyl)-1-pentyl-1H-indazole

반응식

[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][N:8]=[C:7]2[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=1.[H-].[Na+].I[CH2:22][CH2:23][CH2:24][CH2:25][CH3:26]>>[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[N:9]([CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[N:8]=[C:7]2[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=1

참가 물질

반응물 3

HCID 123351-Iodopentane

HCID 24758Sodium hydride

HCID 178489137HCID 178489137, 화합물

생성물 1

HCID 688821427-chloro-3-(4-methoxyphenyl)-1-pentyl-1H-indazole수율 43.8%

실험 절차

Prepared according to Method D step B from 7-chloro-3-(4-methoxyphenyl)-1H-indazole (0.129 g, 0.5 mmol), sodium hydride (60% in oil, 0.024 g, 0.6 mmol) and 1-iodopentane (0.130 mL, 1.0 mmol) to give the title compound (0.072 g) as a white solid.

후처리

customPrepared

출처 및 근거

ORD 기록: ord-a7be657c4c524bb69bfa169d4c99e2de
출처 데이터셋: uspto-grants-2007_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07241791B2

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