Isopropyl iodide → 7-chloro-1-isopropyl-3-(4-methoxyphenyl)-1H-indazole

HRID 1294934노트

반응식

[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][N:8]=[C:7]2[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=1.[H-].[Na+].I[CH:22]([CH3:24])[CH3:23]>>[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[N:9]([CH:22]([CH3:24])[CH3:23])[N:8]=[C:7]2[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=1

참가 물질

반응물 3

HCID 6362Isopropyl iodide

HCID 24758Sodium hydride

HCID 178489137HCID 178489137, 화합물

생성물 1

HCID 688843687-chloro-1-isopropyl-3-(4-methoxyphenyl)-1H-indazole수율 28.6%

실험 절차

Prepared according to Method D step B from 7-chloro-3-(4-methoxyphenyl)-1H-indazole (0.129 g, 0.5 mmol), sodium hydride (60% in oil, 0.024 g, 0.6 mmol) and 2-iodopropane (0.10 mL, 1.0 mmol) to give the title compound (0.043 g) as a white solid.

후처리

customPrepared

출처 및 근거

ORD 기록: ord-4dc22d516a5641cfbcc3fa1f0ad66fef
출처 데이터셋: uspto-grants-2007_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07241791B2

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