Sodium hydride → 3-(4-methoxyphenyl)-1-propyl-7-trifluoromethyl-1H-indazole

HRID 1294940노트

반응식

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:17]3[C:12](=[C:13]([C:18]([F:21])([F:20])[F:19])[CH:14]=[CH:15][CH:16]=3)[NH:11][N:10]=2)=[CH:5][CH:4]=1.[H-].[Na+].I[CH2:25][CH2:26][CH3:27]>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[C:17]3[C:12](=[C:13]([C:18]([F:21])([F:19])[F:20])[CH:14]=[CH:15][CH:16]=3)[N:11]([CH2:25][CH2:26][CH3:27])[N:10]=2)=[CH:7][CH:8]=1

참가 물질

반응물 3

HCID 24758Sodium hydride

HCID 336431-Iodopropane

HCID 178489134HCID 178489134, 화합물

생성물 1

HCID 688822923-(4-methoxyphenyl)-1-propyl-7-trifluoromethyl-1H-indazole수율 34.7%

실험 절차

Prepared according to Method D step B from 3-(4-methoxyphenyl)-7-trifluoromethyl-1H-indazole (0.146 g, 0.5 mmol), sodium hydride (60% in oil, 0.024 g, 0.6 mmol) and 1-iodopropane (0.098 mL, 1.0 mmol) to give the title compound (0.058 g) as a white solid.

후처리

customPrepared

출처 및 근거

ORD 기록: ord-38df4dd17eed4578b144fbd61265c1c5
출처 데이터셋: uspto-grants-2007_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07241791B2

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