Sodium hydride → 3-(4-methoxy-2-methylphenyl)-1-propyl-7-(trifluoromethyl)-1H-indazole

HRID 1294985노트

반응식

HRID 1294985 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:17]3[C:12](=[C:13]([C:18]([F:21])([F:20])[F:19])[CH:14]=[CH:15][CH:16]=3)[NH:11][N:10]=2)=[C:5]([CH3:22])[CH:4]=1.[H-].[Na+].I[CH2:26][CH2:27][CH3:28]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:17]3[C:12](=[C:13]([C:18]([F:21])([F:19])[F:20])[CH:14]=[CH:15][CH:16]=3)[N:11]([CH2:26][CH2:27][CH3:28])[N:10]=2)=[C:5]([CH3:22])[CH:4]=1

참가 물질

4

반응물 3

HCID 24758Sodium hydrideHCID 336431-IodopropaneHCID 178489135HCID 178489135, 화합물

생성물 1

HCID 688846133-(4-methoxy-2-methylphenyl)-1-propyl-7-(trifluoromethyl)-1H-indazole수율 57.4%

실험 절차

Prepared according to Method D step B from 3-(4-methoxy-2-methylphenyl)-7-(trifluoromethyl)-1H-indazole (0.150 g, 0.49 mmol), sodium hydride (60% in oil, 0.025 g, 1.04 mmol) and iodopropane (0.07 mL, 0.7 mmol) to give the title compound (0.098 g) as a white solid.

후처리

  1. customPrepared

출처 및 근거

ORD 기록
ord-46670fdedeb546f3a57cd0e886f57946
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07241791B2

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