Isopropyl iodide → 2-isopropyl 3-(4-methoxyphenyl)-7-trifluoromethyl-2H-indazole

HRID 1295027노트

반응식

HRID 1295027 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:17]3[C:12](=[C:13]([C:18]([F:21])([F:20])[F:19])[CH:14]=[CH:15][CH:16]=3)[NH:11][N:10]=2)=[CH:5][CH:4]=1.[H-].[Na+].I[CH:25]([CH3:27])[CH3:26]>>[CH:25]([N:10]1[C:9]([C:6]2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=2)=[C:17]2[C:12]([C:13]([C:18]([F:21])([F:19])[F:20])=[CH:14][CH:15]=[CH:16]2)=[N:11]1)([CH3:27])[CH3:26]

참가 물질

4

반응물 3

HCID 6362Isopropyl iodideHCID 24758Sodium hydrideHCID 178489134HCID 178489134, 화합물

생성물 1

HCID 688841862-isopropyl 3-(4-methoxyphenyl)-7-trifluoromethyl-2H-indazole수율 23.8%

실험 절차

Prepared according to Method D step B from 3-(4-methoxyphenyl)-7-trifluoromethyl-1H-indazole (1.0 g, 3.4 mmol), sodium hydride (60% in oil, 0.136 g, 3.4 mmol) and 2-iodopropane (0.34 mL, 3.4 mmol) to give the title compound (0.27 g) as a white solid.

후처리

  1. customPrepared

출처 및 근거

ORD 기록
ord-50cc5188b5ae417fa669dcfa6a92c594
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07241791B2

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