Butylamine → 6-Chloro-5-amino-4-butyl pyrimidine

HRID 1295465

반응식

HRID 1295465 반응식
[NH2:1][C:2]1[C:3](Cl)=[N:4][CH:5]=[N:6][C:7]=1[Cl:8].CCN(CC)CC.[CH2:17](N)[CH2:18][CH2:19][CH3:20]>CCCCO>[Cl:8][C:7]1[N:6]=[CH:5][N:4]=[C:3]([CH2:17][CH2:18][CH2:19][CH3:20])[C:2]=1[NH2:1]

참가 물질

5

반응물 3

HCID 8007ButylamineHCID 8471TriethylamineHCID 794345-Amino-4,6-dichloropyrimidine

생성물 1

HCID 858276526-Chloro-5-amino-4-butyl pyrimidine

시약·촉매·용매 1

HCID 2631-Butanol용매

실험 절차

A solution of 5-amino-4,6-dichloropyrimidine (1 mmol) in n-BuOH was treated with Et3N (1.2 mmol) and n-Butylamine (1.0 mmol) at 80 C. After 16 h, solvent was removed under reduced pressure. The residue was dissolved in EtOAc, the organic layer washed with water and then dried (MgSO4). Filtration and removal of solvent gave 6-chloro-5-amino-4-butyl pyrimidine as a brown solid. Rf=0.5 in 1:1 EtOAc:hexane. 1H NMR (CDCl3) δ 8.07 (s, 1H), 4.88 (br s, 1H), 3.49 (m, 2H), 3.35 (br s, 2H), 1.6 (m, 2H), 1.44 (m, 2), 0.95 (t, 3H).

후처리

  1. customsolvent was removed under reduced pressure
  2. dissolutionThe residue was dissolved in EtOAc
  3. washthe organic layer washed with water
  4. dry with materialdried (MgSO4)
  5. filtrationFiltration and removal of solvent

출처 및 근거

ORD 기록
ord-4c96a5f9caf744acb1e89ce41d429c2c
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07241890B2

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