N-bromobutanimide → 6-Bromomethyl-4-methanesulfonyl-3,4-dihydro-2H-benzo[1,4]oxazine

HRID 1295558노트

반응식

HRID 1295558 반응식
[CH3:1][S:2]([N:5]1[C:10]2[CH:11]=[C:12]([CH3:15])[CH:13]=[CH:14][C:9]=2[O:8][CH2:7][CH2:6]1)(=[O:4])=[O:3].[Br:16]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl.[W]>[Br:16][CH2:15][C:12]1[CH:13]=[CH:14][C:9]2[O:8][CH2:7][CH2:6][N:5]([S:2]([CH3:1])(=[O:3])=[O:4])[C:10]=2[CH:11]=1

참가 물질

5

반응물 2

HCID 67184N-bromobutanimideHCID 694178614-Methanesulfonyl-6-methyl-3,4-dihydro-2H-benzo[1,4]oxazine

생성물 1

HCID 694200776-Bromomethyl-4-methanesulfonyl-3,4-dihydro-2H-benzo[1,4]oxazine수율 100%

시약·촉매·용매 2

HCID 23964Tungsten촉매HCID 5943Carbon Tetrachloride용매

실험 절차

4-Methanesulfonyl-6-methyl-3,4-dihydro-2H-benzo[1,4]oxazine (2.0 g, 8.8 mmol) and N-bromosuccinimide (1.88 g, 10.6 mmol) were dissolved in carbon tetrachloride (100 mL) and the mixture heated at reflux under a 250 W tungsten lamp. After 2 h the mixture was cooled to ambient temperature and filtered through Kieselguhr. The combined filtrate and washings were evaporated to dryness under reduced pressure to give the title compound (2.66 g, 100%) as a brown oil.

후처리

  1. temperaturethe mixture heated
  2. filtrationfiltered through Kieselguhr
  3. customThe combined filtrate and washings were evaporated to dryness under reduced pressure

출처 및 근거

ORD 기록
ord-71b8f1b2a2374a98aba49371a4cc6918
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07244726B2

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