Triethyl phosphite → Diethyl 3-Nitrobenzylphosphonate

HRID 1295583노트

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HRID 1295583 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[CH2:7]Br)([O-:3])=[O:2].[P:12]([O:19]CC)([O:16][CH2:17][CH3:18])[O:13][CH2:14][CH3:15]>C1(C)C=CC=CC=1>[N+:1]([C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[CH2:7][P:12](=[O:19])([O:16][CH2:17][CH3:18])[O:13][CH2:14][CH3:15])([O-:3])=[O:2]

참가 물질

4

반응물 2

HCID 31215Triethyl phosphiteHCID 77568Benzene, 1-(bromomethyl)-3-nitro-

생성물 1

HCID 13675396Diethyl 3-Nitrobenzylphosphonate수율 68%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A mixture of 3-nitrobenzyl bromide (17.3 g, 0.08 mol), triethyl phosphite (13.3 g, 0.08 mol) in toluene (200 mL) was stirred at reflux for 24 h. The reaction mixture was cooled and evaporated in vacuo. Chromatography of the residues on SiO2 eluting from 0–100% ethyl acetate in petroleum ether (60–80° C.) gave the title compound (14.8 g, 68%) as a yellow liquid.

후처리

  1. temperatureat reflux for 24 h
  2. temperatureThe reaction mixture was cooled
  3. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-0889e9f234de4bcb8da5c6f93585c8f8
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07244726B2

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