참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ammonium Chloride | HCID 25517 | — |
| 반응물 | 1-(alpha,alpha,alpha-Trifluoro-m-tolyl)acetone | HCID 89101 | — |
| 반응물 | HCID 178418573 | HCID 178418573 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 2-Methyl-1-(3-trifluoromethyl-phenyl)-propan-2-ol | HCID 14974993 | — |
반응 단계
90 mL of a 3 molar solution of methylmagnesium bromide in diethyl ether are diluted with 300 mL THF and cooled to −50° C. At this temperature 20 g 1-(3-trifluoromethyl-phenyl)-propan-2-one, dissolved in 100 mL THF, are added dropwise. After the addition has ended the reaction mixture is stirred overnight while heating to ambient temperature. It is combined with ammonium chloride solution and extracted with diethyl ether. The combined organic phases are washed with sodium chloride solution, dried with sodium sulphate and evaporated down. The residue remaining is purified by chromatography.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07244728B2 |
|---|
| 출처 데이터셋 | uspto-grants-2007_07 |
|---|
| ORD ID | ord-2a031326e45f4a968da9f97965d6ff33 |
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| 출처 메모 | uspto-grants-2007_07 |
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