反应详情

温度

-50 °C

90 mL of a 3 molar solution of methylmagnesium bromide in diethyl ether are diluted with 300 mL THF and cooled to −50° C. At this temperature 20 g 1-(3-trifluoromethyl-phenyl)-propan-2-one, dissolved in 100 mL THF, are added dropwise. After the addition has ended the reaction mixture is stirred overnight while heating to ambient temperature. It is combined with ammonium chloride solution and extracted with diethyl ether. The combined organic phases are washed with sodium chloride solution, dried with sodium sulphate and evaporated down. The residue remaining is purified by chromatography.

1. additionare added dropwise
2. additionAfter the addition
3. temperaturewhile heating to ambient temperature
4. extractionextracted with diethyl ether
5. washThe combined organic phases are washed with sodium chloride solution
6. dry with materialdried with sodium sulphate
7. customevaporated down
8. customThe residue remaining is purified by chromatography