Sodium Hydroxide → HCID 58909200, 화합물

HRID 1295613노트

반응식

HRID 1295613 반응식
[CH2:1]([NH:8][C:9]([C:11]1[CH:15]=[CH:14][O:13][C:12]=1[NH:16][C:17](=O)[CH2:18][CH2:19][CH3:20])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>C(O)CO>[CH2:1]([N:8]1[C:9](=[O:10])[C:11]2[CH:15]=[CH:14][O:13][C:12]=2[N:16]=[C:17]1[CH2:18][CH2:19][CH3:20])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 58909201HCID 58909201, 화합물

생성물 1

HCID 58909200HCID 58909200, 화합물

시약·촉매·용매 1

HCID 174Ethylene Glycol용매

반응 조건

온도
130 °C

실험 절차

A mixture of N-benzyl-2-(butyrylamino)-3-furamide (1-2, 1 equiv) and sodium hydroxide (0.1 equiv) in ethylene glycol is heated at 130° C. for 5 h. The reaction mixture is allowed to cool, then partitioned between a half-saturated aqueous sodium chloride solution and ethyl acetate. The combined organic layers are dried over sodium sulfate and concentrated. The residue is purified by flash column (hexanes initially, grading to 100% ethyl acetate) to provide 3-benzyl-2-propylfuro[2,3-d]pyrimidin-4(3H)-one (1-3).

후처리

  1. temperatureto cool
  2. custompartitioned between a half-saturated aqueous sodium chloride solution and ethyl acetate
  3. dry with materialThe combined organic layers are dried over sodium sulfate
  4. concentrationconcentrated
  5. customThe residue is purified by flash column (hexanes initially

출처 및 근거

ORD 기록
ord-26d96abbd1654d44b6d78cefdad46c82
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07244723B2

반응 노트

불러오는 중…