(4-Butyl-phenyl)-[4-(2-methanesulfonyl-benzoimidazol-1-yl)-piperidin-1-yl]-methanone → (4-Butyl-phenyl)-[4-(2-hexylamino-benzoimidazol-1-yl)-piperidin-1-yl]-methanone

HRID 1295774

반응식

HRID 1295774 반응식
[CH2:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]([N:13]2[CH2:18][CH2:17][CH:16]([N:19]3[C:23]4[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=4[N:21]=[C:20]3S(C)(=O)=O)[CH2:15][CH2:14]2)=[O:12])=[CH:7][CH:6]=1)[CH2:2][CH2:3][CH3:4]>C(N)CCCCC.C(#N)C.O>[CH2:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]([N:13]2[CH2:18][CH2:17][CH:16]([N:19]3[C:23]4[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=4[N:21]=[C:20]3[NH:13][CH2:11][CH2:8][CH2:7][CH2:6][CH2:5][CH3:1])[CH2:15][CH2:14]2)=[O:12])=[CH:7][CH:6]=1)[CH2:2][CH2:3][CH3:4]

참가 물질

4

반응물 1

HCID 69240993(4-Butyl-phenyl)-[4-(2-methanesulfonyl-benzoimidazol-1-yl)-piperidin-1-yl]-methanone

생성물 1

HCID 69240836(4-Butyl-phenyl)-[4-(2-hexylamino-benzoimidazol-1-yl)-piperidin-1-yl]-methanone수율 101.8%

시약·촉매·용매 2

HCID 8102Hexylamine촉매HCID 18373917Acetonitrile--water (1/1)용매

실험 절차

In a sealed glass tube, (4-butyl-phenyl)-[4-(2-methanesulfonyl-benzoimidazol-1-yl)-piperidin-1-yl]-methanone (9 mg) and hexyl amine (3 drops) were heated at 120-150° C. for 18 h. The crude product was taken into 1 ml 1:1 acetonitrile/water and purified via preparative liquid chromatography to give (4-butyl-phenyl)-[4-(2-hexylamino-benzoimidazol-1-yl)-piperidin-1-yl]-methanone (4.8 mg).

후처리

  1. custompurified via preparative liquid chromatography

출처 및 근거

ORD 기록
ord-44a2ef12a0f64059957e2f9213b5a80a
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07244744B2

연결된 노트

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