Diethyl Ether → 5-Bromo-1-tert-butyl-2-methoxy-3-nitrobenzene

HRID 1295959

반응식

HRID 1295959 반응식
[C:1](=O)([O-])[O-].[K+].[K+].CI.[Br:9][C:10]1[CH:15]=[C:14]([N+:16]([O-:18])=[O:17])[C:13]([OH:19])=[C:12]([C:20]([CH3:23])([CH3:22])[CH3:21])[CH:11]=1.CCOCC>CN(C)C=O>[CH3:1][O:19][C:13]1[C:14]([N+:16]([O-:18])=[O:17])=[CH:15][C:10]([Br:9])=[CH:11][C:12]=1[C:20]([CH3:23])([CH3:22])[CH3:21]

참가 물질

6

반응물 4

HCID 3283Diethyl EtherHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 229297864-Bromo-2-tert-butyl-6-nitrophenol

생성물 1

HCID 229301475-Bromo-1-tert-butyl-2-methoxy-3-nitrobenzene수율 90.2%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
50 °C

실험 절차

Potassium carbonate (453 g) and methyl iodide (164 ml) were added to a solution of 4-bromo-2-(tert-butyl)-6-nitrophenol (600 g) in dimethylformamide (6000 ml) and the mixture was stirred at 50° C. for 4 hours. Ether (6000 ml) was added and the reaction mixture was washed 3 times with water. The organic layer was dried over anhydrous magnesium sulfate and the solvent was distilled off under reduced pressure to yield a crude product of the title compound (569 g) as a yellow oil.

후처리

  1. washthe reaction mixture was washed 3 times with water
  2. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  3. distillationthe solvent was distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-0a6cf78a88ae42a49b522045688b1bef
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07244730B2

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