N-bromobutanimide → 5-Bromo-3-fluoro-2-hydroxybenzaldehyde
반응식
[F:1][C:2]1[C:3]([OH:10])=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=[O:6].[Br:11]N1C(=O)CCC1=O>C(#N)C.C(OCC)(=O)C>[Br:11][C:8]1[CH:9]=[C:2]([F:1])[C:3]([OH:10])=[C:4]([CH:7]=1)[CH:5]=[O:6]참가 물질
5
실험 절차
596 mg of 3-fluoro-2-hydroxybenzaldehyde was dissolved in 5 ml of acetonitrile, and 770 mg of N-bromosuccinimide was added. The solution was stirred for 15 minutes at room temperature. The reaction mixture was diluted with ethyl acetate, and washed with water and saturated brine and dried over anhydrous magnesium sulfate. The solution was filtered and the solvent was evaporated, to give 928 mg of 5-bromo-3-fluoro-2-hydroxybenzaldehyde.
후처리
- washwashed with water and saturated brine
- dry with materialdried over anhydrous magnesium sulfate
- filtrationThe solution was filtered
- customthe solvent was evaporated
출처 및 근거
- ORD 기록
- ord-ce3a698aac8640afbe3048ef15a0ed5c
- 출처 데이터셋
- uspto-grants-2007_07
- 특허 번호
- US07244861B2
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