N-Iodosuccinimide → HCID 22494282, 화합물

반응식

[CH2:1]([O:3][C:4](=[O:28])[CH:5]([O:24][CH:25]([CH3:27])[CH3:26])[CH2:6][C:7]1[CH:12]=[C:11]([CH2:13][NH:14][C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[C:10]([OH:22])=[C:9](Br)[CH:8]=1)[CH3:2].[I:29]N1C(=O)CCC1=O>C(#N)C.C(OCC)(=O)C>[CH2:1]([O:3][C:4](=[O:28])[CH:5]([O:24][CH:25]([CH3:27])[CH3:26])[CH2:6][C:7]1[CH:12]=[C:11]([CH2:13][NH:14][C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[C:10]([OH:22])=[C:9]([I:29])[CH:8]=1)[CH3:2]

참가 물질

실험 절차

253 mg of 3-(3-bromo-5-[(t-butoxycarbonyl)amino]methyl-4-hydroxyphenyl)-2-isopropoxypropionic acid ethyl ester was dissolved in 3 ml of acetonitrile, and 157 mg of N-iodosuccinimide was added. After stirring for 2.5 days at room temperature, the reaction mixture was diluted with ethyl acetate. The organic layer was washed with water and saturated sodium thiosulfate water, and dried over anhydrous magnesium sulfate, and the solvent was evaporated. The residue was purified by silica gel column chromatography, and 100 mg of 3-(3-iodo-5-[(t-butoxycarbonyl)amino]methyl-4-hydroxyphenyl)-2-isopropoxypropionic acid ethyl ester was obtained from fractions eluted with hexane-ethyl acetate (4:1).