Acetic Anhydride → N-(hydroxymethyl)acetamide acetate

HRID 129623노트

반응식

HRID 129623 반응식
[C:1]([O:4]C(=O)C)(=[O:3])[CH3:2].[OH:8][CH2:9][NH:10][C:11](=[O:13])[CH3:12]>N1C=CC=CC=1>[C:1]([OH:4])(=[O:3])[CH3:2].[OH:8][CH2:9][NH:10][C:11](=[O:13])[CH3:12]

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 69365Formicin

생성물 1

HCID 86745977N-(hydroxymethyl)acetamide acetate수율 900%

시약·촉매·용매 1

HCID 1049Pyridine촉매

실험 절차

Acetic anhydride (25 g) and pyridine (10 drops) is added to N-(hydroxymethyl)acetamide (9 g, 0.1 mol). The reaction mixture is stirred overnight at room temperature, concentrated in vacuo and chased with xylene to give the title product as an oil (11.9 g, 0.9 mol) which is identified by 1HNMR spectral analysis.

후처리

  1. concentrationconcentrated in vacuo and chased with xylene

출처 및 근거

ORD 기록
ord-7c0bd3edec95447594664c9e2887776d
출처 데이터셋
uspto-grants-1995_11
특허 번호
US05468877

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