Hydrochloric Acid → Cinacalcet Hydrochloride

HRID 1296838

반응식

HRID 1296838 반응식
[CH3:1][C@@H:2]([NH:13][CH2:14][CH2:15][CH2:16][C:17]1[CH:18]=[CH:19][CH:20]=[C:21]([C:23]([F:26])([F:25])[F:24])[CH:22]=1)[C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=12.[ClH:27]>C(OCC(C)C)(=O)C>[CH3:1][C@@H:2]([NH:13][CH2:14][CH2:15][CH2:16][C:17]1[CH:18]=[CH:19][CH:20]=[C:21]([C:23]([F:24])([F:25])[F:26])[CH:22]=1)[C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=12.[ClH:27]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 156419Cinacalcet

생성물 1

HCID 156418Cinacalcet Hydrochloride

시약·촉매·용매 1

HCID 8038Isobutyl Acetate용매

실험 절차

0.3 g of cinacalcet base was dissolved in 4 ml of isobutyl acetate at room temperature, i.e., about 20° to about 25° C. Then, 2 ml of 1N HCl were added in one portion, and the mixture was stirred at room temperature overnight, yielding a precipitate. The product was isolated by filtration, washed with 5 ml of isobutyl acetate, and dried at 50° C. in a vacuum oven for 24 hours, yielding 0.12 g of cinacalcet hydrochloride crystalline Form I.

후처리

  1. customi.e., about 20° to about 25° C
  2. customyielding a precipitate
  3. customThe product was isolated by filtration
  4. washwashed with 5 ml of isobutyl acetate
  5. customdried at 50° C. in a vacuum oven for 24 hours

출처 및 근거

ORD 기록
ord-91fddeac19ad41778c823f1730f626b8
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07247751B2

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