Hydrazine hydrate (1:1) → 4-(5-methyl-4-phenyl-1H-pyrazol-3-yl)benzene-1,3-diol

HRID 1296918노트

반응식

HRID 1296918 반응식
[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=O)[C:7]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[C:8]([CH3:12])[O:9]2)=[CH:4][CH:3]=1.O.[NH2:21][NH2:22]>C(O)C>[CH3:12][C:8]1[NH:22][N:21]=[C:6]([C:5]2[CH:4]=[CH:3][C:2]([OH:1])=[CH:11][C:10]=2[OH:9])[C:7]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 53809767-hydroxy-2-methyl-3-phenyl-4H-chromen-4-one

생성물 1

HCID 9369204-(5-methyl-4-phenyl-1H-pyrazol-3-yl)benzene-1,3-diol

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

This compounds was synthesised in the same manner as described above. 7-Hydroxy-2-methyl-3-phenyl-chromen-4-one (0.5 g, 1.70 mmol), hydrazine hydrate (5 ml), ethanol (10 ml). The quenched solution was extracted into ethyl acetate, washed (water), dried (MgSO4), and the solvent removed under vacuum to give a yellow oil which was purified by column chromatography to give 4-(5-Methyl-4-phenyl-1H-pyrazol-3-yl)-benzene-1,3-diol as an off white solid (0.37 g, 88%); Rf 0.7 Cf SM 0.8 ethyl acetate/hexane (80/20).

후처리

  1. customThis compounds was synthesised in the same manner
  2. extractionThe quenched solution was extracted into ethyl acetate
  3. washwashed (water)
  4. dry with materialdried (MgSO4)
  5. customthe solvent removed under vacuum
  6. customto give a yellow oil which
  7. customwas purified by column chromatography

출처 및 근거

ORD 기록
ord-403181738b0a42d7b1a9af64ac077139
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07247734B2

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