2-Methylresorcinol → 4-chloro-2-methyl-benzene-1,3-diol

HRID 1296949노트

반응식

HRID 1296949 반응식
[CH3:1][C:2]1[C:8]([OH:9])=[CH:7][CH:6]=[CH:5][C:3]=1[OH:4].[Cl:10]N1C(=O)CCC1=O>CC#N>[Cl:10][C:7]1[CH:6]=[CH:5][C:3]([OH:4])=[C:2]([CH3:1])[C:8]=1[OH:9]

참가 물질

4

반응물 2

HCID 118432-MethylresorcinolHCID 31398Chlorosuccinimide

생성물 1

HCID 112059244-chloro-2-methyl-benzene-1,3-diol

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

To a solution of 2-methyl resorcinol (1 eq) in MeCN (5 ml) was added N-chlorosuccinimide (1 eq) and refluxed under nitrogen overnight. The yellow solution was concentrated in vacuo and purified by flash chromatography to give 4-chloro-2-methyl-benzene-1,3-diol as a solid.

후처리

  1. temperaturerefluxed under nitrogen overnight
  2. concentrationThe yellow solution was concentrated in vacuo
  3. custompurified by flash chromatography

출처 및 근거

ORD 기록
ord-f3c5f8a7f317437cbd1645ce25c08484
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07247734B2

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