Dimethylformamide → HCID 58913661, 화합물

HRID 1296951노트

반응식

HRID 1296951 반응식
[Cl:1][C:2]1[C:3]([OH:21])=[C:4]([CH3:20])[C:5]([OH:19])=[C:6]([C:8](=[O:18])[CH2:9][C:10]2[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=2)[CH:7]=1.CN(C=O)C.C([O-])([O-])=O.[K+].[K+].[C:33](OC(=O)C)(=O)[CH3:34]>O>[Cl:1][C:2]1[CH:7]=[C:6]2[C:5](=[C:4]([CH3:20])[C:3]=1[OH:21])[O:19][C:33]([CH3:34])=[C:9]([C:10]1[CH:11]=[CH:12][C:13]([O:16][CH3:17])=[CH:14][CH:15]=1)[CH:8]2[OH:18]

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 7918Acetic AnhydrideHCID 11430Potassium CarbonateHCID 58913540HCID 58913540, 화합물

생성물 1

HCID 58913661HCID 58913661, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a solution of 1-(5-chloro-2,4-dihydroxy-3-methyl-phenyl)-2-(4-methoxy-phenyl)-ethanone (1 eq) in an. DMF (7 ml) was added K2CO3 (3 eq). Acetic anhydride (3 eq) was added dropwise to the solution, which was then refluxed under nitrogen whilst stirring for 5 h. The solution was taken up in water and extracted using ethyl acetate, dried over MgSO4 and concentrated in vacuo to give 6-chloro-3-(4-methoxy-phenyl)-2,8-dimethyl-4H-chromene-4,7-diol as a crystalline solid.

후처리

  1. temperaturewas then refluxed under nitrogen
  2. extractionextracted
  3. dry with materialdried over MgSO4
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-bf85aa3446604a58a04d70bd7402924b
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07247734B2

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