Hydrogen Bromide → 2-Bromo-4-fluoro-6-nitroaniline
반응식
[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([N+:9]([O-:11])=[O:10])[CH:3]=1.[BrH:12].BrBr>O>[F:1][C:2]1[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[C:5]([NH2:6])=[C:7]([Br:12])[CH:8]=1참가 물질
5
반응 조건
- 온도
- 7 °C
실험 절차
Mix 4-fluoro-2-nitroaniline (15.6 g, 0.1 mol) in water (400 mL) and add 48% hydrobromic acid (1kg). Add bromine (16 g, 0.1 mol) with stirring and stir for 1 hour. Dilute to 2L and cool to 7° C. Filter, wash with water and dry to give 4-fluoro-2-bromo-6-nitroaniline.
후처리
- filtrationFilter
- washwash with water
- customdry
출처 및 근거
- ORD 기록
- ord-aa8ecdb05e154ce489facf8685c73331
- 출처 데이터셋
- uspto-grants-1995_11
- 특허 번호
- US05470870
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