Hydroxide → HCID 59007054, 화합물

HRID 130477노트

반응식

HRID 130477 반응식
[CH3:1][C@H:2]1[NH:7][C@@H:6]([CH3:8])[CH2:5][N:4]([C:9]2[CH:10]=[CH:11][C:12]([O:31]CC3C=CC=CC=3)=[C:13]([NH:15][S:16]([C:19]3[CH:24]=[CH:23][C:22]([C:25]4[O:26][C:27]([CH3:30])=[CH:28][CH:29]=4)=[CH:21][CH:20]=3)(=[O:18])=[O:17])[CH:14]=2)[CH2:3]1.[OH-]>C(O)C.CN(C)C=O>[CH3:8][C@H:6]1[NH:7][C@@H:2]([CH3:1])[CH2:3][N:4]([C:9]2[CH:10]=[CH:11][C:12]([OH:31])=[C:13]([NH:15][S:16]([C:19]3[CH:24]=[CH:23][C:22]([C:25]4[O:26][C:27]([CH3:30])=[CH:28][CH:29]=4)=[CH:21][CH:20]=3)(=[O:18])=[O:17])[CH:14]=2)[CH2:5]1

참가 물질

5

반응물 2

HCID 961HydroxideHCID 69196742HCID 69196742, 화합물

생성물 1

HCID 59007054HCID 59007054, 화합물

시약·촉매·용매 2

HCID 702Ethanol용매HCID 6228Dimethylformamide용매

실험 절차

A solution of N-{5-(cis-3,5-dimethyl-1-piperazinyl)-2-[(phenylmethyl)oxy]phenyl}-4-(5-methyl-2-furanyl)benzenesulfonamide (D43) (100 mg, 0.19 mmol) in ethanol (4 ml) and N,N-dimethylformamide (2.5 ml) was treated with palladiwn hydroxide on carbon (25 mg) and the mixture stirred under an atmosphere of hydrogen for 3.75 h. The mixture was then filtered through celite, washing with ethanol and the filtrate reduced in vacuo and the residue purified by mass directed autoprep HPLC to afford the title compound. MS (ES+) m/e 442 [M+H]+.

후처리

  1. filtrationThe mixture was then filtered through celite
  2. washwashing with ethanol
  3. customthe residue purified by mass

출처 및 근거

ORD 기록
ord-a8519bb8b1e6467eaa8551e0b0d993c5
출처 데이터셋
uspto-grants-2008_06
특허 번호
US07381728B2

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