Sodium Hydroxide → 3-(2,4-difluorophenyl)propanoic Acid

HRID 130607

반응식

HRID 130607 반응식
[F:1][C:2]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:3]=1[CH:4]=[CH:5][C:6]([OH:8])=[O:7].[OH-].[Na+].[H][H]>[Pd]>[F:1][C:2]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:3]=1[CH2:4][CH2:5][C:6]([OH:8])=[O:7]

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 6035023-(2,4-Difluorophenyl)acrylic AcidHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 49863953-(2,4-difluorophenyl)propanoic Acid수율 85%

시약·촉매·용매 1

HCID 23938Palladium촉매

반응 조건

온도
100 °C

실험 절차

The procedure was as in Example 5, but the 2,4-difluorocinnamic acid obtained was not isolated. The aqueous-acidic product suspension obtained was rendered alkaline using sodium hydroxide solution and treated with 2 g of Pd/C (5% strength) at 50° C. with further stirring and heated to 100° C. It was then pressurized to 5 bar of hydrogen. After constant pressure had been achieved, it was cooled to room temperature, the pressure was released and the palladium catalyst was filtered off. The alkaline product solution was acidified with sulfuric acid and the product precipitate was isolated by filtration. After drying in vacuo, 95.0 g of 3-(2,4-difluorophenyl)propionic acid (85% of theory) were obtained.

후처리

  1. customwas not isolated
  2. customThe aqueous-acidic product suspension obtained
  3. temperatureit was cooled to room temperature
  4. filtrationthe palladium catalyst was filtered off
  5. customthe product precipitate was isolated by filtration
  6. customAfter drying in vacuo

출처 및 근거

ORD 기록
ord-9e4e1d0e34434b238fee93adb46af9bf
출처 데이터셋
uspto-grants-2008_06
특허 번호
US07381832B2

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