Sodium hydride → 5-(4-[1,3]Dioxolan-2-ylphenoxy)pyridine-2-carboxamide

HRID 130833

반응식

HRID 130833 반응식
[O:1]1[CH2:5][CH2:4][O:3][CH:2]1[C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=1.[H-].[Na+].F[C:16]1[CH:17]=[CH:18][C:19]([C:22]([NH2:24])=[O:23])=[N:20][CH:21]=1>CN(C=O)C>[O:1]1[CH2:5][CH2:4][O:3][CH:2]1[C:6]1[CH:11]=[CH:10][C:9]([O:12][C:16]2[CH:17]=[CH:18][C:19]([C:22]([NH2:24])=[O:23])=[N:20][CH:21]=2)=[CH:8][CH:7]=1

참가 물질

5

반응물 3

HCID 24758Sodium hydrideHCID 113211644-[1,3]dioxolan-2-ylphenolHCID 219047545-Fluoropyridine-2-carboxamide

생성물 1

HCID 687495285-(4-[1,3]Dioxolan-2-ylphenoxy)pyridine-2-carboxamide

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Dissolve 4-[1,3]dioxolan-2-ylphenol (Part C2, 0.471 g, 2.85 mmol) in DMF (89.5 mL). Add NaH (80% in mineral oil) (0.128 g, 4.28 mmol). Stir at room temperature for about an hour before adding 5-fluoropyridine-2-carboxamide (0.400 g, 2.85 mmol). Heat at 80° C. for 4.5 hours before concentrating to dryness to form 5-(4-[1,3]dioxolan-2-ylphenoxy)pyridine-2-carboxamide.

후처리

  1. temperatureHeat at 80° C. for 4.5 hours
  2. concentrationbefore concentrating to dryness

출처 및 근거

ORD 기록
ord-a3e46bba254348b2973c86384e1449e7
출처 데이터셋
uspto-grants-2008_06
특허 번호
US07381719B2

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