Hydrogen Peroxide → 3,5-Difluoro-4-(4-formyl-phenoxy)benzamide

HRID 130950노트

반응식

HRID 130950 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([F:19])[C:9]=1[O:10][C:11]1[CH:16]=[CH:15][C:14]([CH:17]=[O:18])=[CH:13][CH:12]=1)[C:5]#[N:6].OO.C(=O)([O-])[O-:23].[K+].[K+]>CS(C)=O>[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([F:19])[C:9]=1[O:10][C:11]1[CH:16]=[CH:15][C:14]([CH:17]=[O:18])=[CH:13][CH:12]=1)[C:5]([NH2:6])=[O:23]

참가 물질

5

반응물 3

HCID 784Hydrogen PeroxideHCID 11430Potassium CarbonateHCID 597299063,5-Difluoro-4-(4-formyl-phenoxy)benzonitrile

생성물 1

HCID 597301093,5-Difluoro-4-(4-formyl-phenoxy)benzamide수율 99%

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

Hydrolysis of the compound of step 1 using hydrogen peroxide and potassium carbonate in DMSO as described previously afford the above compound in 99% yield.

후처리

  1. customas described previously afford the above compound in 99% yield

출처 및 근거

ORD 기록
ord-570b439bbeaa477595bd8b058a5caa2d
출처 데이터셋
uspto-grants-2008_06
특허 번호
US07381719B2

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