참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | (4-Fluorophenyl)hydrazine | HCID 69982 | — |
| 반응물 | 4-Chloro-2-fluoro-5-methoxybenzaldehyde | HCID 14928268 | — |
| 용매 | 1-Methylpyrrolidine | HCID 8454 | — |
| 생성물 | 1-(4-Fluorophenyl)-6-chloro-5-methoxy-1H-indazole | HCID 59339887 | — |
반응 단계
4-Chloro-2-fluoro-5-methoxy benzaldehyde (204 mg, 1.1 mmol) and 4-fluorophenylhydrazine (176 mg, 1.1 mmol) were dissolved in N-methylpyrrolidine (5 mL). After addition of cesium carbonate (1.15 g, 3.3 mmol) the mixture was heated in a microwave reactor (CEM Discovery, 150 Watt) to 150° C. for 20 min. After dilution with DCM the mixture was washed with sat. NaHCO3, brine and the organic phase was evaporated. After purification of the crude by flash chromatography on silica gel 253 mg (84%) of the subtitle compound were obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07728030B2 |
|---|
| 출처 데이터셋 | uspto-grants-2010_06 |
|---|
| ORD ID | ord-c1adadd15d2a4e29a6a6d4c16ded8b2c |
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| 출처 메모 | uspto-grants-2010_06 |
|---|
