反应详情

温度

150 °C

4-Chloro-2-fluoro-5-methoxy benzaldehyde (204 mg, 1.1 mmol) and 4-fluorophenylhydrazine (176 mg, 1.1 mmol) were dissolved in N-methylpyrrolidine (5 mL). After addition of cesium carbonate (1.15 g, 3.3 mmol) the mixture was heated in a microwave reactor (CEM Discovery, 150 Watt) to 150° C. for 20 min. After dilution with DCM the mixture was washed with sat. NaHCO3, brine and the organic phase was evaporated. After purification of the crude by flash chromatography on silica gel 253 mg (84%) of the subtitle compound were obtained.

1. washAfter dilution with DCM the mixture was washed with sat. NaHCO3, brine
2. customthe organic phase was evaporated
3. customAfter purification of the crude by flash chromatography on silica gel 253 mg (84%) of the subtitle compound
4. customwere obtained