Hydrochloric Acid → HCID 178517399, 화합물

HRID 131201

반응식

HRID 131201 반응식
Cl.[NH2:2][C:3]1[CH:7]=[CH:6][S:5][C:4]=1[C:8]([O:10]C)=O.[CH:12]1([C:15]#[N:16])[CH2:14][CH2:13]1.[NH4+].[OH-]>O1CCOCC1.O>[CH:12]1([C:15]2[N:16]=[C:8]([OH:10])[C:4]3[S:5][CH:6]=[CH:7][C:3]=3[N:2]=2)[CH2:14][CH2:13]1

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 14923Ammonium HydroxideHCID 79637CyclopropanecarbonitrileHCID 89652Methyl 3-amino-2-thiophenecarboxylate

생성물 1

HCID 178517399HCID 178517399, 화합물수율 72%

시약·촉매·용매 2

HCID 962Water용매HCID 312751,4-Dioxane용매

실험 절차

Dry HCl gas was bubbled through a solution of methyl 3-aminothiophene-2-carboxylate (1.64 g, 10.4 mmol) and cyclopropanecarbonitrile (27 mL) in dioxane (40 mL) for 1 h then the reaction mixture was diluted with cold water (2 volumes), basified with NH4OH (50 mL) and the resulting solid filtered and air dried to give the title compound (1.44 g, 72%) as a white solid: IR νmax (Nujol)/cm−1 2925, 1664, 1597, 788; NMR δH (400 MHz, DMSO) 1.04 (4H, m), 2.00 (1H, m), 7.20 (1H, d J 5.0 Hz), 8.10 (1H, d, J 5.0 Hz) and 12.60 (1H,br).

후처리

  1. filtrationthe resulting solid filtered
  2. customair dried

출처 및 근거

ORD 기록
ord-ec448f144c3441c5b13a1991b7d268fa
출처 데이터셋
uspto-grants-2008_06
특허 번호
US07384949B2

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