Hydrochloric Acid → (2S)-2-Amino-1-(3-fluorophenyl)-4-methyl-pentane-1-ol hydrochloride
반응식
C(OC(=O)[NH:7][C@H:8]([CH:13]([C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([F:21])[CH:16]=1)[OH:14])[CH2:9][CH:10]([CH3:12])[CH3:11])(C)(C)C.[ClH:23]>O1CCOCC1>[ClH:23].[NH2:7][C@@H:8]([CH2:9][CH:10]([CH3:12])[CH3:11])[CH:13]([C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([F:21])[CH:16]=1)[OH:14]참가 물질
4
실험 절차
The aforementioned described {(S)-1-[(3-fluorophenyl)-hydroxymethyl]-3-methylbutyl}-carbamic acid tert.-butylester (4.7 g, 15.1 mmol) is dissolved in dioxane (37 mL). After addition of HCl in dioxane (37.7 mL of a 4M solution) the reaction mixture is stirred for 4 h. After evaporation of the solvent the crude product (3.7 g, 99.5%) is used in the next step without further purification.
후처리
- customAfter evaporation of the solvent the crude product (3.7 g, 99.5%)
- customis used in the next step without further purification
출처 및 근거
- ORD 기록
- ord-02040c98ae3a4c6690c4b3023b1340ac
- 출처 데이터셋
- uspto-grants-2010_06
- 특허 번호
- US07728030B2
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