Acetoin → 2-Amino-4,5-dimethyl-3-furancarbonitrile

HRID 131288

반응식

HRID 131288 반응식
[C:1](#[N:5])[CH2:2][C:3]#[N:4].[OH:6][CH:7]([CH3:11])[C:8](=O)[CH3:9].C(NCC)C>CO>[NH2:4][C:3]1[O:6][C:7]([CH3:11])=[C:8]([CH3:9])[C:2]=1[C:1]#[N:5]

참가 물질

5

반응물 3

HCID 179AcetoinHCID 8010MalononitrileHCID 8021Diethylamine

생성물 1

HCID 2902202-Amino-4,5-dimethyl-3-furancarbonitrile수율 75%

시약·촉매·용매 1

HCID 887Methanol용매2회

반응 조건

온도
10 °C

실험 절차

To a solution of malononitrile (28.2 g) in methanol (30 mL) is added a suspension of acetoin (25 g) in methanol (30 mL) and thereto is added dropwise diethylamine (11 mL) under ice-cooling (internal temp.: 10° C.). The mixture is stirred at room temperature for 3 hours. The reaction mixture is poured into ice water (300 mL) and the precipitated crystals are collected by filtration to give 2-amino-4,5-dimethyl-3-furonitrile (28.91 g, yield; 75%) as colorless crystals.

후처리

  1. filtrationthe precipitated crystals are collected by filtration

출처 및 근거

ORD 기록
ord-e457f56050504f0fa27764bfa1e56fd1
출처 데이터셋
uspto-grants-2008_06
특허 번호
US07384952B2

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