Stannous chloride dihydrate → HCID 136388576, 화합물

HRID 131379

반응식

HRID 131379 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[S:10][CH:11]=[CH:12][C:13]=2[C:14]#[N:15])=[C:4]([N+:16]([O-])=O)[CH:3]=1.O.O.[Sn](Cl)Cl>C(O)C.Cl>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]2[NH:8][C:9]3[S:10][CH:11]=[CH:12][C:13]=3[C:14]([NH2:15])=[N:16][C:4]=2[CH:3]=1

참가 물질

5

반응물 2

HCID 61436Stannous chloride dihydrateHCID 692103022-(4-Chloro-2-nitro-phenylamino)-thiophene-3-carbonitrile

생성물 1

HCID 136388576HCID 136388576, 화합물수율 142.2%

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 702Ethanol용매

실험 절차

Suspend 2-(4-chloro-2-nitro-phenylamino)-thiophene-3-carbonitrile (4.85 g, 17.35 mmol) in ethanol (40.0 ml). Dissolve tin(II) chloride dihydrate (11.75 g, 52.06 mmol) in 5N HCl (40.0 ml) and then add it to the suspension. Heat the reaction at reflux for 48 hours. Cool the reaction to ambient temperature and then chill it in a refrigerator for 2 hours. Collect the resulting precipitate by vacuum filtration and then dry it under vacuum to give 3.53 g (71%) of the title compound: mass spectrum (ion spray): m/z=250.0 (M+1).

후처리

  1. temperatureHeat
  2. customthe reaction
  3. temperatureat reflux for 48 hours
  4. temperatureCool
  5. customthe reaction to ambient temperature
  6. temperaturechill it in a refrigerator for 2 hours
  7. customCollect the resulting precipitate
  8. filtrationby vacuum filtration
  9. customdry it under vacuum

출처 및 근거

ORD 기록
ord-623c2cee87cf4f29af7e5b80f35fc012
출처 데이터셋
uspto-grants-2008_06
특허 번호
US07384934B2

연결된 노트

불러오는 중…