Ammonia → 2-(1-(4-fluorophenyl)-1H-indazol-5-yloxy)-2-phenylacetamide

HRID 13169

반응식

HRID 13169 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]3[C:11](=[CH:12][C:13]([O:17][CH:18]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)[C:19]([O:21]C)=O)=[CH:14][CH:15]=3)[CH:10]=[N:9]2)=[CH:4][CH:3]=1.[NH3:29]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]3[C:11](=[CH:12][C:13]([O:17][CH:18]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)[C:19]([NH2:29])=[O:21])=[CH:14][CH:15]=3)[CH:10]=[N:9]2)=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 222AmmoniaHCID 59339649methyl 2-(1-(4-fluorophenyl)-1H-indazol-5-yloxy)-2-phenylacetate

생성물 1

HCID 593397222-(1-(4-fluorophenyl)-1H-indazol-5-yloxy)-2-phenylacetamide

실험 절차

A suspension of methyl 2-(1-(4-fluorophenyl)-1H-indazol-5-yloxy)-2-phenylacetate (137c, 75 mg, 200 μmol) in methanolic NH3 (7 M, 1 ml) was stirred at r.t. overnight to give a clear solution. Then the solvent was removed in vacuo, and the crude product was freeze-dried go give white solid material, 60 mg (83%).

후처리

  1. customto give a clear solution
  2. customThen the solvent was removed in vacuo
  3. dry with materialthe crude product was freeze-dried go
  4. customgive white solid material, 60 mg (83%)

출처 및 근거

ORD 기록
ord-81d60e2148214d4e864b058f4eaadea7
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728030B2

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