참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | 4-Fluorophenylhydrazine hydrochloride | HCID 69981 | — |
| 반응물 | 2-(Fluoromethoxy)benzaldehyde | HCID 20061507 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 생성물 | 1-(4-Fluorophenyl)-5-methoxy-1H-indazole | HCID 59339622 | — |
반응 단계
A mixture of 2-fluoromethoxybenzaldehyde (2.1 mmol, 320 mg), 4-fluorophenylhydrazine hydrochloride (2.1 mmol, 340 mg) and cesium carbonate (3 mmol, 2.0 g) in NMP (6 ml) was heated in a microwave reactor (300 W, 20 min, 150° C.). After cooling to r.t. the reaction mixture was diluted with dichloromethane (20 ml) and washed with 1M HCl, and sat. NaHCO3. The organic layer was dried over Na2SO4, concentrated, and purified by flash chromatography on silica gel (heptane-ethyl acetate).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07728030B2 |
|---|
| 출처 데이터셋 | uspto-grants-2010_06 |
|---|
| ORD ID | ord-c8e87cd6e7c044e2b1f536b44b2227db |
|---|
| 출처 메모 | uspto-grants-2010_06 |
|---|
