反应详情

温度

150 °C

A mixture of 2-fluoromethoxybenzaldehyde (2.1 mmol, 320 mg), 4-fluorophenylhydrazine hydrochloride (2.1 mmol, 340 mg) and cesium carbonate (3 mmol, 2.0 g) in NMP (6 ml) was heated in a microwave reactor (300 W, 20 min, 150° C.). After cooling to r.t. the reaction mixture was diluted with dichloromethane (20 ml) and washed with 1M HCl, and sat. NaHCO3. The organic layer was dried over Na2SO4, concentrated, and purified by flash chromatography on silica gel (heptane-ethyl acetate).

1. temperatureAfter cooling to r.t. the reaction mixture
2. washwashed with 1M HCl, and sat. NaHCO3
3. dry with materialThe organic layer was dried over Na2SO4
4. concentrationconcentrated
5. custompurified by flash chromatography on silica gel (heptane-ethyl acetate)