2-Aminothiazole → 1-(Cyclopentyloxy)-2-nitrobenzene

HRID 131850

반응식

HRID 131850 반응식
[CH:1]1([OH:6])[CH2:5][CH2:4][CH2:3][CH2:2]1.F[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[N+:14]([O-:16])=[O:15].[CH:17]1([O:22][C:23]2[CH:29]=[CH:28][CH:27]=[CH:26][C:24]=2[NH2:25])[CH2:21][CH2:20][CH2:19][CH2:18]1.[NH2:30][C:31]1[S:32][CH:33]=[CH:34][N:35]=1>>[CH:1]1([O:6][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[N+:14]([O-:16])=[O:15])[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:17]1([O:22][C:23]2[CH:29]=[CH:28][CH:27]=[CH:26][C:24]=2[NH:25][C:1]([NH:30][C:31]2[S:32][CH:33]=[CH:34][N:35]=2)=[O:6])[CH2:21][CH2:20][CH2:19][CH2:18]1

참가 물질

6

반응물 4

HCID 21552-AminothiazoleHCID 7298CyclopentanolHCID 738951-Fluoro-2-nitrobenzeneHCID 64853982-(Cyclopentyloxy)aniline2회

생성물 2

HCID 221644731-(Cyclopentyloxy)-2-nitrobenzene수율 80%HCID 59732940N-(2-Cyclopentyloxyphenyl)-N'-(thiazol-2-yl)urea수율 70%

실험 절차

2-(Cyclopentyloxy)-1-nitrobenzene (1.04 g, 80%) was prepared from cyclopentanol (0.46 ml, 5.0 mmol) and 1-fluoro-2-nitrobenzene (0.71 g, 5.0 mmol) following the general procedure G. This was reduced to 2-(cyclopentyloxy)aniline (0.30 g, 68%, 2.5 mmol scale) following general procedure B. N-(2-Cyclopentyloxyphenyl)-N′-(thiazol-2-yl)urea (212 mg, 70%) was prepared from 2-(cyclopentyloxy)aniline (177 mg, 1.0 mmol) and 2-aminothiazole (100 mg, 1.0 mmol) following the general procedure D.

출처 및 근거

ORD 기록
ord-5965329d61114efba728c2a7f4bb51c0
출처 데이터셋
uspto-grants-2008_06
특허 번호
US07384967B2

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