Methyl iodide → 1-Ethyl-1-methyl-4-oxopiperidin-1-ium iodide

HRID 132041

반응식

HRID 132041 반응식
[CH2:1]([N:3]1[CH2:8][CH2:7][C:6](=[O:9])[CH2:5][CH2:4]1)[CH3:2].[CH3:10][I:11]>CC(C)=O>[I-:11].[CH2:1]([N+:3]1([CH3:10])[CH2:8][CH2:7][C:6](=[O:9])[CH2:5][CH2:4]1)[CH3:2]

참가 물질

4

반응물 2

HCID 6328Methyl iodideHCID 771591-Ethylpiperidin-4-one

생성물 1

HCID 110975681-Ethyl-1-methyl-4-oxopiperidin-1-ium iodide수율 84.9%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a solution of 1-ethyl-4-oxopiperidine (25 g, 0.197 mol) in acetone (250 ml) at RT in a water bath was added methyl iodide (15.5 ml, 0.25 mol) at such a rate to keep the temperature below 30° C. The mixture was filtered and the precipitate washed with acetone and dried to yield 1- ethyl-1-methyl-4-oxopiperidinium iodide (45 g) (LC/MS: Rt 0.38, [M+H]+143).

후처리

  1. customthe temperature below 30° C
  2. filtrationThe mixture was filtered
  3. washthe precipitate washed with acetone
  4. customdried

출처 및 근거

ORD 기록
ord-c1ee797730da4f8fad6f5e4912466d0d
출처 데이터셋
uspto-grants-2008_06
특허 번호
US07385059B2

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