Trifluoroacetic acid → N-{1-(S)-[1-(R)-Benzyloxymethyl-2-(5-fluoro-2,3-dihydro-indol-1-yl)-ethylcarbamoyl]-2-cyclohexyl-ethyl}-3-methoxy-benzamide

HRID 132142

반응식

HRID 132142 반응식
C(O[C:6](=[O:40])[NH:7][C@H:8]([C:16](=[O:39])[NH:17][C@@H:18]([CH2:30][O:31][CH2:32]C1C=CC=CC=1)[CH2:19][N:20]1[C:28]2[C:23](=[CH:24][C:25]([F:29])=[CH:26][CH:27]=2)[CH2:22][CH2:21]1)[CH2:9][CH:10]1[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1)(C)(C)C.F[C:42](F)(F)[C:43](O)=O.C(O)(=O)[C:49]1[CH:54]=[CH:53][CH:52]=[C:51]([O:55][CH3:56])[CH:50]=1.CN(C(ON1N=N[C:69]2[CH:70]=[CH:71]C=N[C:68]1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.C(N(C(C)C)CC)(C)C>C(OCC)(=O)C.ClCCl.O>[CH2:32]([O:31][CH2:30][C@H:18]([NH:17][C:16]([C@@H:8]([NH:7][C:6](=[O:40])[C:53]1[CH:54]=[CH:49][CH:50]=[C:51]([O:55][CH3:56])[CH:52]=1)[CH2:9][CH:10]1[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15]1)=[O:39])[CH2:19][N:20]1[C:28]2[C:23](=[CH:24][C:25]([F:29])=[CH:26][CH:27]=2)[CH2:22][CH2:21]1)[C:43]1[CH:42]=[CH:71][CH:70]=[CH:69][CH:68]=1

참가 물질

9

반응물 5

HCID 6422Trifluoroacetic acidHCID 114613-Methoxybenzoic AcidHCID 81531DiisopropylethylamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 69196165{1-(S)-[1-(R)-Benzyloxymethyl-2-(5-fluoro-2,3-dihydro-indol-1-yl)-ethylcarbamoyl]-2-cyclohexyl-ethyl}-carbamic acid tert-butyl ester

생성물 1

HCID 69195896N-{1-(S)-[1-(R)-Benzyloxymethyl-2-(5-fluoro-2,3-dihydro-indol-1-yl)-ethylcarbamoyl]-2-cyclohexyl-ethyl}-3-methoxy-benzamide수율 87%

시약·촉매·용매 3

HCID 962Water용매HCID 6344Dichloromethane용매2회HCID 8857Ethyl Acetate용매

실험 절차

A sample of {1-(S)-[1-(R)-Benzyloxymethyl-2-(5-fluoro-2,3-dihydro-indol-1-yl)-ethylcarbamoyl]-2-cyclohexyl-ethyl}-carbamic acid tert-butyl ester (210 mg, 0.34 mmol) was treated with a mixture of trifluoroacetic acid, dichloromethane and water (45:45:10) and allowed to age for 2 hours. The solvent was then removed by rotary evaporation. The resulting oil was treated with m-anisic acid (75 mg, 0.49 mmol), HATU (187 mg, 0.49 mmol) and dichloromethane (2 mL). The reaction was then treated with diisopropylethylamine (245 mg, 1.9 mmol) and stirred for 2 hours. The reaction was diluted with ethyl acetate, extracted with saturated aqueous NaHCO3 twice, dried over MgSO4 and the solvent was removed. The resulting oil was purified over silica gel using a gradient of 0 to 100% ethyl acetate in hexane to afford 195 mg (87%) of the title material; 1H NMR (CDCl3, 400 MHz) δ 0.84-1.03 (m, 2H), 1.06-1.22 (m, 3H), 1.32-1.45 (m, 1H), 1.58-1.87 (m, 7H), 2.92 (dd, 1H, J1=J2=8.2), 3.13-3.25 (m, 2H), 3.31-3.46 (m, 2H), 3.54 (dd, 1H, J1=54.2, J2=9.4), 3.68 (dd, 1H, J1=2.4, J2=9.3), 3.84 (s, 3H), 4.26-4.36 (m, 1H), 4.53 (dd, 2H, J1=11.8, J2=26.0), 4.65-4.74 (m, 1H), 6.46 (dd, 1H, J1=4.1, J2=8.4), 6.46 (d, 1H, J=8.3), 6.69-6.83 (m, 2H), 7.02-7.09 (m, 1H), 7.27-7.39 (m, 7H); HPLC-MS calcd. for C35H42FN3O4 (M+H+) 587.3, found 587.5.

후처리

  1. customThe solvent was then removed by rotary evaporation
  2. extractionextracted with saturated aqueous NaHCO3 twice
  3. dry with materialdried over MgSO4
  4. customthe solvent was removed
  5. customThe resulting oil was purified over silica gel using a gradient of 0 to 100% ethyl acetate in hexane

출처 및 근거

ORD 기록
ord-42ea1a4a92ae48aa9889d3a1d874903b
출처 데이터셋
uspto-grants-2008_06
특허 번호
US07384970B2

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