Hydrazine hydrate (1:1) → (4-(4-fluoro-phenoxy)-6-(pyridin-3-yloxy)-1H-benzimidazol-2-yl)-hydrazine
반응식
O.[NH2:2][NH2:3].[F:4][C:5]1[CH:28]=[CH:27][C:8]([O:9][C:10]2[C:18]3[N:17]=[C:16](S)[NH:15][C:14]=3[CH:13]=[C:12]([O:20][C:21]3[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=3)[CH:11]=2)=[CH:7][CH:6]=1>C(OCC)(=O)C>[F:4][C:5]1[CH:28]=[CH:27][C:8]([O:9][C:10]2[C:18]3[N:17]=[C:16]([NH:2][NH2:3])[NH:15][C:14]=3[CH:13]=[C:12]([O:20][C:21]3[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=3)[CH:11]=2)=[CH:7][CH:6]=1참가 물질
4
반응 조건
- 온도
- 130 °C
실험 절차
1.0 ml of hydrazine monohydrate was added to 130 mg of 4-(4-fluoro-phenoxy)-6-(pyridin-3-yloxy)-1H-benzimidazole-2-thiol, and the reaction liquid was stirred overnight at 130° C. The reaction liquid was diluted with ethyl acetate, washed with water and saturated saline in order, and dried with anhydrous magnesium sulfate. The solvent was evaporated away under reduced pressure, and the resulting residue was purified through partitioning thin-layer chromatography (Kieselgel™ 60F254, Art 5744 (by Merck), hexane/ethyl acetate=1/1) to obtain the entitled compound.