Methanol → 5-Acetyl-2-amino-4-methylthiazole

HRID 132529

반응식

HRID 132529 반응식
[NH2:1][C:2]([NH2:4])=[S:3].N1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.C[OH:12]>>[NH2:1][C:2]1[S:3][C:8]([C:9](=[O:12])[CH3:10])=[C:7]([CH3:6])[N:4]=1

참가 물질

4

반응물 3

HCID 887MethanolHCID 1049PyridineHCID 2723790Thiourea

생성물 1

HCID 7208825-Acetyl-2-amino-4-methylthiazole

실험 절차

A mixture of thiourea (5.18 g, 0.068 mol) in dry MeOH (20 ML) was stirred and cooled on an ice bath. Pyridine (2 mL) was added, followed by 3-chloro-2,4-pentadione (9.15 g, 0.068 mol) dropwise. After completion of the addition the reaction mixture was allowed to warm to r. t. and stirring was continued for 4 h. The precipitates were filtered and washed with EtOAc to afford white solid 1-(2-amino-4-methyl-thiazol-5-yl)-ethanone.

후처리

  1. temperaturecooled on an ice bath
  2. additionAfter completion of the addition the reaction mixture
  3. temperatureto warm to r
  4. stirringand stirring
  5. filtrationThe precipitates were filtered
  6. washwashed with EtOAc

출처 및 근거

ORD 기록
ord-687520a4f5be4f46b80e1aa46430e6a0
출처 데이터셋
uspto-grants-2008_06
특허 번호
US07388015B2

연결된 노트

불러오는 중…