Sodium Hydroxide → HCID 23145661, 화합물

HRID 13264노트

반응식

HRID 13264 반응식
[OH-].[Na+].[C:3]([N:6]1[CH2:10][CH2:9][CH2:8][CH:7]1[C:11]1[CH:12]=[C:13]([CH:19]=[CH:20][C:21]=1[O:22][CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[C:14]([O:16]CC)=[O:15])(=[O:5])[CH3:4]>C(O)C>[C:3]([N:6]1[CH2:10][CH2:9][CH2:8][CH:7]1[C:11]1[CH:12]=[C:13]([CH:19]=[CH:20][C:21]=1[O:22][CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[C:14]([OH:16])=[O:15])(=[O:5])[CH3:4]

참가 물질

4

반응물 2

HCID 14798Sodium Hydroxide2회HCID 23145505Ethyl 3-(1-acetyl-pyrrolidin-2-yl)-4-benzyloxybenzoate

생성물 1

HCID 23145661HCID 23145661, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

23 ml of aqueous 4 N sodium hydroxide solution was added to an ethanol (200 ml) solution of 18.7 g of ethyl 3-(1-acetyl-pyrrolidin-2-yl)-4-benzyloxybenzoate, and the reaction liquid was stirred overnight at room temperature. 15 ml of aqueous 4 N sodium hydroxide solution was added to the reaction liquid, and the reaction liquid was stirred for 7 hours. The reaction solvent was evaporated away under reduced pressure, and the resulting residue was diluted with water, and washed with ether. The aqueous layer was acidified with 6 N hydrochloric acid added thereto, then extracted with chloroform, and dried with anhydrous magnesium sulfate. The solvent was evaporated away under reduced pressure to obtain the entitled compound as a white solid.

후처리

  1. customthe reaction liquid
  2. customthe reaction liquid
  3. stirringwas stirred for 7 hours
  4. customThe reaction solvent was evaporated away under reduced pressure
  5. additionthe resulting residue was diluted with water
  6. washwashed with ether
  7. additionadded
  8. extractionextracted with chloroform
  9. dry with materialdried with anhydrous magnesium sulfate
  10. customThe solvent was evaporated away under reduced pressure

출처 및 근거

ORD 기록
ord-ac1fe18f368b4f6eb81e87d8e5fb4747
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728025B2

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