Pyridine → HCID 23125865, 화합물

HRID 132732

반응식

HRID 132732 반응식
[C:1]1([C:9]2[C:10]([CH2:15][OH:16])=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:2]([CH2:7][OH:8])=[CH:3][CH:4]=[CH:5][CH:6]=1.N1C=C[CH:20]=[CH:19][CH:18]=1.[C:23](Cl)(=[O:30])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1.[O:32]1[CH2:36][CH2:35][CH2:34][CH2:33]1>>[C:23]([O:16][CH2:15][C:10]1[C:9]([C:1]2[C:2]([CH2:7][O:8][C:36](=[O:32])[C:35]3[CH:20]=[CH:19][CH:18]=[CH:33][CH:34]=3)=[CH:3][CH:4]=[CH:5][CH:6]=2)=[CH:14][CH:13]=[CH:12][CH:11]=1)(=[O:30])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

참가 물질

5

반응물 4

HCID 1049PyridineHCID 7412Benzoyl chlorideHCID 8028TetrahydrofuranHCID 243265(1,1'-Biphenyl)-2,2'-dimethanol

생성물 1

HCID 23125865HCID 23125865, 화합물수율 93%

실험 절차

To 0.03 mol 2,2′-biphenyldimethanol was added 30 ml tetrahydrofuran and 0.09 mol pyridine, then added 0.075 mol benzoyl chloride with stirring. The reaction mixture was heated refluxing for 4 hours, cooled and added 20 ml saturated saline. The mixture was extracted with ethyl acetate, and extract was dried over anhydrous sodium sulfate. The solvent was removed. Column chromatography gave 2,2′-biphenyldimethanol dibenzoate as a colorless viscous liquid, and the yield was 93%.

후처리

  1. temperatureThe reaction mixture was heated
  2. temperaturerefluxing for 4 hours
  3. temperaturecooled
  4. additionadded 20 ml saturated saline
  5. extractionThe mixture was extracted with ethyl acetate
  6. extractionextract
  7. dry with materialwas dried over anhydrous sodium sulfate
  8. customThe solvent was removed

출처 및 근거

ORD 기록
ord-95eff78e70df4997a65f9cd5b2102bbd
출처 데이터셋
uspto-grants-2008_06
특허 번호
US07388061B2

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