Di-tert-butyl dicarbonate → Tert-Butyl (2S)-2-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-hydroxyethylcarbamate

HRID 132803노트

반응식

HRID 132803 반응식
[NH2:1][CH2:2][C@@H:3]([C@H:5]1[CH2:9][O:8][C:7]([CH3:11])([CH3:10])[O:6]1)[OH:4].[O:12](C(OC(C)(C)C)=O)[C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=O>C1COCC1>[CH3:10][C:7]1([CH3:11])[O:6][C@@H:5]([C@@H:3]([OH:4])[CH2:2][NH:1][C:13](=[O:12])[O:15][C:16]([CH3:19])([CH3:18])[CH3:17])[CH2:9][O:8]1

참가 물질

4

반응물 2

HCID 90495Di-tert-butyl dicarbonateHCID 59734745(1S)-2-amino-1-[(4r)-2,2-dimethyl-1,3-dioxolan-4-yl]ethanol

생성물 1

HCID 14249481Tert-Butyl (2S)-2-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-hydroxyethylcarbamate

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Aminoalcohol 23 was dissolved in THF and BOC2O was added and stirred for several hrs. The solvent was removed and the product purified using silica gel chromatography.

후처리

  1. customThe solvent was removed
  2. customthe product purified

출처 및 근거

ORD 기록
ord-6dacd23111d34dacac13d12d18d78972
출처 데이터셋
uspto-grants-2008_06
특허 번호
US07388118B2

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