Sodium borohydride → HCID 58687965, 화합물
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[Br:1][C:2]1[C:9]([O:10][CH3:11])=[N:8][C:7]([C:12]([F:15])([F:14])[F:13])=[C:6]([Br:16])[C:3]=1[CH:4]=[O:5].[BH4-].[Na+]>C(O)C>[Br:1][C:2]1[C:9]([O:10][CH3:11])=[N:8][C:7]([C:12]([F:15])([F:14])[F:13])=[C:6]([Br:16])[C:3]=1[CH2:4][OH:5]참가 물질
4
실험 절차
To a solution of 3,5-dibromo-2-methoxy-6-(trifluoromethyl)isonicotinaldehyde (980 mg, 2.7 mmol) in ethanol (10 mL) was added sodium borohydride (102 mg, 2.7 mmol). The reaction mixture was stirred for 20 min, concentrated, and the residue was purified by flash chromatography (silica gel; 50% ethyl acetate/hexanes as eluant) to yield the title compound. 1H NMR (400 MHz, CDCl3) δ 5.10 (s, 2H), 4.05 (s, 3H), 2.32 (br s, 1H).
후처리
- concentrationconcentrated
- customthe residue was purified by flash chromatography (silica gel; 50% ethyl acetate/hexanes as eluant)
출처 및 근거
- ORD 기록
- ord-6ccd91e590644054bdb496793e368843
- 출처 데이터셋
- uspto-grants-2008_06
- 특허 번호
- US07388019B2
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