Trifluoroacetic acid → 2-Methyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine, trifluoroacetate salt

HRID 132864

반응식

HRID 132864 반응식
C(OC([N:8]1[CH2:18][CH2:17][C:11]2[N:12]=[C:13]([CH3:16])[N:14]=[CH:15][C:10]=2[CH2:9]1)=O)(C)(C)C.[F:19][C:20]([F:25])([F:24])[C:21]([OH:23])=[O:22]>ClCCl>[F:19][C:20]([F:25])([F:24])[C:21]([OH:23])=[O:22].[CH3:16][C:13]1[N:14]=[CH:15][C:10]2[CH2:9][NH:8][CH2:18][CH2:17][C:11]=2[N:12]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 69223447tert-Butyl 2-methyl-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate

생성물 1

HCID 1317269312-Methyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine, trifluoroacetate salt

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Reaction of the product from Step A above with trifluoroacetic acid in dichloromethane according to the procedure outlined for Intermediate 28, Step C afforded the title compound as a light orange powder. LC/MS 150.1 (M+1).

출처 및 근거

ORD 기록
ord-6e4a4110fd734a84b43ed6b6d96031e2
출처 데이터셋
uspto-grants-2008_06
특허 번호
US07388019B2

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